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Let’s Talk About the Complications of Obesity

Source: Health Central, HEALTH WRITER Aug 3, 2020


As if the social stigma of living with obesity wasn’t taxing enough, the condition brings with it myriad health challenges that can be difficult to manage—and increasing a person’s risk for other serious medical conditions. We take a look at the long term ramifications of this disease, and what it takes to start making healthier choices.



What Exactly Is Obesity?

Most people with obesity are aware of their condition as are those around them. Unlike so-called “silent diseases” like high blood pressure, osteoporosis, and pancreatic cancer— which often develop without us realizing it—obesity is a highly visible medical condition that occurs when an individual’s body accumulates and stores excess amounts of body fat.

The clinical definition of obesity is measured using a person’s Body Mass Index (BMI) and excess fat resulting in a BMI of 30 or higher can be a key symptom of obesity. BMI is an imperfect measure, for sure. For instance, it doesn’t distinguish between fat and muscle, so a fit and muscular person and a sedentary person could share the same BMI. However, it’s a good rough gauge of whether your body fat is in the healthy range.


Calculating Your BMI To determine your BMI, plug your numbers into our BMI calculator or use this simple equation: Divide your weight (in pounds) by your height (in centimeters) squared Multiply that number by 703 = your BMI


For adults, a BMI of 25-29.9 is considered overweight by most doctors and a BMI of 30 or more is considered obese. For example, a woman who stands 5’4” and weighs 175 pounds is considered obese (BMI = 30); the same goes for a man who stands 5’9” and weighs 204 pounds (BMI = 30.3).


Symptoms of Obesity Though it’s the most visible symptom of obesity, a high BMI isn’t the only symptom of this condition. A person with obesity might also often experience:

  • Shortness of breath: Extra fat in your neck, on your chest or across your abdomen can make it difficult to take a deep breath or can otherwise affect your breathing patterns, which may make you feel sluggish, sleepy or breathless.

  • Chafing between the legs: This happens when skin rubs together, creating friction. Obesity is the most common cause, but chafing also occurs in athletes with super-defined quads.

  • Stretch marks: If you've gained a lot of weight quickly, you might develop these telltale parallel lines as your skin stretches to accommodate.

  • Varicose veins: Excess fat in the legs may hide varicose veins, but you may experience a feeling of heaviness, pain, swelling or skin changes, and if so, you should tell your doctor.

  • Joint pain, as the hips, knees, and ankles carry excess weight: You might experience this as you climb the stairs, or stoop down to pick something up off the floor.

These aren’t just annoyances but are part of a constellation of issues those who struggle with obesity must contend with.


Complications of Obesity When thinking about the dangers of obesity, the second leading cause of preventable death in the country, it’s important to look past the obvious physical symptoms and consider the longer term ramifications. A better word for symptoms in this case is complications or comorbidities.

A comorbidity is a medical condition that is caused by or related to another medical condition; in terms of obesity, many studies have linked obesity with more than 200 chronic diseases and acts as a gateway to some truly serious health conditions. Below are a handful of the most common issues associated with obesity:


Heart-Related Conditions Obesity has consistently been linked with an elevated risk for heart-related conditions such as: High Blood Pressure Carrying around excess amounts of weight puts pressure on the heart, forcing it to work harder to send blood throughout the body. This can result in elevated blood pressure, a frequent cause of heart attacks. The system-wide inflammation caused by obesity also creates blood pressure-related problems, because it causes blood vessels to become stiffer than they should be. Stiff blood vessels, in turn, raise blood pressure. Cholesterol Obesity can cause your “bad” cholesterol (LDL, or low-density lipoproteins) to increase, while lowering levels of your “good” (HDL, or high-density lipoproteins) cholesterol. Both changes increase the risk for heart disease. Coronary Heart Disease People with obesity, particularly those who carry much of their excess fat around the middle, increase their chances of developing atherosclerosis, a condition in which plaque (a waxy substance composed of cholesterol, blood-clotting materials, and other substances) builds up on the inner walls of blood vessels throughout the body, including in the heart.

When that happens, it becomes trickier for blood to flow through and reach the heart, causing coronary heart disease, a life-threatening condition. Atherosclerosis can lead to:

  • Reduced oxygen flow to the heart

  • Chest pain

  • Heart attack or stroke

During a heart attack, blood flow to a part of the heart becomes blocked; if blood flow is cut off completely, a part of the heart muscle will begin to die. In a stroke, a similar phenomenon happens, but in a blood vessel that feeds the brain.


Heart Failure This condition, also called congestive heart failure, compromises the heart’s ability to effectively pump blood. (Although “heart failure” sounds like the heart stops beating, it doesn’t. It becomes overtaxed, making it harder to meet the body’s demand for blood and oxygen.) Excess body weight is considered an independent risk factor for heart failure. This means a person with obesity is more likely to suffer from heart failure, even if he or she doesn’t have high blood pressure, high cholesterol, or other comorbidities. In the famed Framingham Heart Study, researchers found that individuals with obesity had a staggering 104 percent increase in the risk of developing heart failure compared to those at a healthy weight. Those with severe obesity (those with a BMI of over 40) were more than four times more likely to have heart failure than subjects with healthy BMIs, even after taking possible complicating factors like high blood pressure and high cholesterol into account, according to a study in the Journal of the American Heart Association.

Why is obesity so closely linked with heart failure? It may be because extra body weight is harder on the heart. Another possibility: Fat cells may release inflammatory chemicals that are toxic to the heart.

Scarring of the Heart Living with obesity can also cause your body to accumulate fat in and surrounding the heart, called epicardial or pericardial fat. These lipid deposits, sometimes called “islands” of fat, can create inflammation and scarring, both of which place additional stress on this supremely important organ.


Type 2 Diabetes About 90 percent of people with Type 2 diabetes are overweight or have obesity. What’s the connection? It may be because excess weight causes cells to become resistant to insulin, the hormone that transports sugar from blood to muscle and fat cells, where it can be used for energy. With insulin resistance, sugar lingers far too long in your blood, spurring inflammation. High blood sugar can spur serious health problems like:

  • Heart disease

  • Stroke

  • Kidney disease

  • Amputation

  • Blindness

Genetics weighs heavily here; a family history of diabetes means you’re far likelier to develop it yourself if you gain weight. You inherit certain genes that make body insulin resistant, especially when insulin secretion goes up. Here’s how diabetes develops:

  1. As you gain weight—even a small amount, like five pounds—you develop more tissue in your body. That means you need more glucose, or sugar, which is the body’s main source of fuel. (An analogy would be that a larger car needs more gasoline to run compared to a smaller car.)

  2. In turn, your pancreas starts secreting insulin, a growth hormone that acts like a key, opening up cells in the body and allowing glucose to enter. Over time, especially if you have a genetic history of diabetes, your body will resist, or ignore, these surging insulin levels.

  3. Your pancreas then responds by turning up the dial, pumping out even more insulin. (Picture a shouting match between your pancreas and your genes.)

  4. Since insulin is a growth hormone, it promotes weight gain. As insulin levels rise, more pounds are put on.

  5. Eventually (it may be years to decades), your pancreas will say, “Enough is enough. I can’t keep pumping out insulin like this. I’m done.”

  6. With no place for the glucose to go, so it builds up in the blood. Chronically elevated blood sugar levels lead to type 2 diabetes.

You don’t need to carry a tremendous amount of excess weight to start this cycle in motion. In fact, gaining just 11-18 pounds doubles your risk of developing Type 2 diabetes; thirty percent of people with obesity will develop the condition.


Cancer Up to 40 percent of all cancers are caused by, or linked with, obesity. In fact, studies show that obesity causes up to 90,000 cancer deaths per year. Doctors have found connections between obesity and cancers of the:

  • Colon and rectum (specifically in men)

  • Breast (specifically in post-menopausal women)

  • Esophagus

  • Gall bladder

  • Kidney

  • Liver

  • Ovary

  • Pancreas

  • Thyroid

Cancer happens when cells in a part of the body grow abnormally or in an out-of-control manner. We don’t know exactly why obesity—or even just being overweight—seems to drive cancer rates, but one theory is that because insulin is a growth hormone, it can act as fuel for any abnormal, pre-cancerous cells that may be hiding in the body, causing them to thrive. Poor eating habits and/or a lack of physical activity habits also increases the risk of cancer.


What’s the Good News? While a look at these symptoms and complications is sobering, there is a ray of light: many of these conditions can be improved—and possibly reversed. While losing weight can feel like a Herculean step, with the right method, or a combination of methods, you can significantly improve your health.

Losing 10% of your body weight seems to be the figure to shoot for, as it’s known to improve various heart-related risk factors. In a recent study, U.K. researchers found that losing 10 percent of one’s body weight in the year following a Type 2 diabetes diagnosis led to diabetic remission. Shedding that same 10 percent also offers a 90 percent chance of curing sleep apnea.

Weight loss can be much more complicated than just “eat less, move more,” but treatments for obesity do exist. Check out our HealthCentral.com Obesity Treatments page for the information you need to take the first steps on your weight-loss journey.


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